The Valen lab is dedicated to the study of gene regulation and RNA biology. We use a combination of experimental and computational approaches to analyze and model regulation trying to understand the integrative effects of transcription and translation.
High throughput assays have revealed that not only transcription, but also translation is a pervasive process. It takes place over 5′ leaders, 3′ trailers and over what we previously thought to be non-coding RNAs predominantly encoding micropeptides. We aim to understand what regulates this non-canonical translation and its potential function.